COVID vaccinations and fertility complications

COVID vaccinations and fertility complications

 There are very real risks to fertility for those who take the COVID injections, and Dr Luke McLindon has the early data.



TRANSCRIPT:

Thanks very much, Jewel and the Voting Matters crew. It’s a great opportunity for us to be here amongst you because I guess it does give us an opportunity just to present our understanding of what the truth is in our own clinical practice. And I think that’s a critical part of the story that we’re not hearing. So thank you for your time and attention.

I guess this is me. Ordinarily I’m a surgeon. I’m a gynecological surgeon with a special interest in infertility and endometriosis surgery and that’s looked after me and my family very well and my patients for many years. The challenge with all of this is that at some point you get to the point in a career where you can’t keep making allowances for dishonesty. And that’s where I’m at. And so I’m stuck on the roundabout, but I don’t know that that’s a really big issue. Now that we’re starting to see some cracks. For me. Thanks.

Now that we’re starting to see some cracks in the the barrier of the barricade I think it’s really important that we do open our hearts to recognize that there are so many people who haven’t taken the opportunity to go a little bit further and scratch beyond the surface to find out what the truth really is in as as it relates to them. And so I think yes, there are people out there trying to silence us. The recent health regulation Health Practitioners Amendment bill that was passed is a disaster and we all recognize that we’re all on the pulse there, but unfortunately it’s only going to become more and more apparent and so for me in my own personal and professional career the point the line in the sand was back in the first of November last year; and so interestingly today is my first anniversary for having (last) operating on the patient my last patient I’ve read on was on the 25th of October last year.

So that’s a bit of a sort of it’s a pain to that. And this is where I think this one is is helpful and worthy of being aware of and humility particularly in this context is about being honest and being accepting of the truth when it presents itself and that’s I think our challenge and each one of your challenges is to try and get that message out in a kind careful cautious and loving way so that people are actually open to listening to what you’ve got to say and and that will win hearts and friends and ultimately take this whole thing down. 

Lots of writing here, but at the end of the day what we’re trying to put out was in terms of pregnancy, the impact of COVID on pregnancy is really not as bad as they made out. It took four cases of zika before it became apparent that zika has a significant impact on pregnancy. Whereas we were well into the pandemic before we sort of started to say 'Well there seems to be an increased risk of preterm birth that ptb thing up there and it seems really increased risk of stillbirth, but it’s very hard to put it all into context'. And certainly there is a case series recently of about 60 infants that sadly died of stillbirth in the setting of a mother having had COVID and found that there is a particular thing that’s very rare called placentitis, which is an inflammation of the placenta which in essence shuts down the placenta from functioning leading to stillbirth, but it’s not every baby. It’s really quite uncommon.

So normal rates of stillbirth about one in 800 term pregnancies. That is a pregnancy beyond 37 weeks in the setting. Also if you had 800 people with covid, it’s about 1.6. So it is increased but it’s only very very small and that’s the barrow they push to say well we need to vaccinate all of them. So we’ll just scratch through a little bit of that as well.

The other thing and I only had this today brought back home, which is the last line but the director general of Queensland Health of the Department of Health brought out on the 29th of September a correction or an update memo to the directive. So the directive came out in the 11th of September to say everyone Queensland Health needs to be vaccinated on the 29th. And this was a it was a point where I thought wow. There’s a little bit of sense here that we will be allowance for pregnancy exemption for anyone who was pregnant at the time of the directive 11th of September until they returned from maternity leave. So that that was reasonable. The challenge is of course the poor woman who finds out that she was pregnant on the 12th of September is not eligible for the exemption.

And in fact, I had a lady today who’s on maternity leave and she has been threatened quite seriously in writing for actually taking her maternity leave back off her because they haven’t she hasn’t provided any proof of vaccination and yet the directive was very clear the memo came out saying she’s exempt until she comes back from maternity leave. So they’re trying any foul trick to scare people and bully people into this.

I think when we talk about vaccinations, we’ve just really got to be careful of understanding, you know, and I think I’ve mentioned this before is when a new product comes to market it’ll always be its best.  A new car; It’ll be fantastic until you realize that the bearings are wrong or something not quite right and it’s exactly the same with any medical product. You’re going to have the best you can present the safest the most effective, etc. It’ll come out with a glowing school report until it starts to hit the ground running and we start to realize that there’s there’s chinks in the armor.

And so we need to recognize that there’s known and unknown harms and benefits. We just need to be honest about that. And the reality is that hasn’t been honest at all. And the minute that it starts to lose the gloss, they just go back layer upon layer of silicon just to allow the story not to stick just to keep buffing it up and make it look good.

The ace2 receptors are probably very aware of the fact that the spike protein which is the problem in this whole covid saga is that the spike protein attaches to the ACE2 receptor and that’s all the way through women’s reproductive tracks. So yes, it’s in cardiovascular systems. It’s in renal systems and affects multi systems, but particularly for women in the reproductive tract. Additionally, there’s some more recent evidence that is actually a pre-print.

So you’re probably very familiar with pre-print now probably never heard of it 12-13 months ago, but there is a pre-print showing that it also affects estrogen which one of the core hormones of women. It affects its estrogen production at a cellular level at a nuclear the nucleus of the cell. So there’s two reasons why women particularly will will be harmed you would expect by covid in the first instance, but also the purified pathology part of covid in terms of vaccine.

As a gynecologist has a particular interest in infertility my job, I guess is to go back and say well what’s that what impact of the Vac these vaccines have on my patients? Because I need to be able to be honest and tell them what the particular this is about informed consent the knowns the unknowns, what are the particular things we need to be aware of if you were to approach your GP and get vaccinated preconception, so before pregnancy, during pregnancy early pregnancy, or in breastfeeding. And it became very apparent very quickly that there just wasn’t information that I could make a call on and that’s very new. That’s quite unique.

Normally you should be able to go through scratch the surface, look around at some of these papers that are referenced in a lot of the guideline documents and and not just read the abstract the front sort of little the conclusion but actually read the nuts and bolts because often the conclusion that’s presented in the abstract.  It comes out of thin air.

It’s like hell on Earth did they get that conclusion out of what they’ve just written, and that happens more and more and more frequently of late.  But these are just some freedom of information application numbers that relate to reproduction and in essence some of the things that we worry about are the lipid nanoparticle, which is the little wrapping around the MRNA component of the vaccine seems to have a preponderance for the ovaries. So 10 times higher concentration in the ovaries the most other areas of the body aside from the liver in this plane, but the ovaries don’t have the ability to regenerate or reconstitute themselves unlike liver.

So that that’s a problem the controls when they looked at the mice models with our rats rather than mice with our rat models and they found that in the control group the miscarriage rate was a whole lot less in fact half. So 4.1% versus 9.8% compared to the actual intervention arm. That is the actual Pfizer that Pfizer had three doses in this study, but the found that it was 9.8% it automatically that should sort of at least raise some concerns. It doesn’t they just passed it aside and said that’s okay it fits in historical miscarriage rates for these sort of studies.

The Freedom of Information 2565 is still undergoing an application. So it just it’s been put in rejected come back adjusted put in again rejected come back. It’s gone to the information commissioner. It’s gone the out Ombudsman. It’s a formal complaint as of interestingly. It’s first anniversary as well 25th of October and it’s still an unresolved issue. You’d think they are after the crown jewels. They’re not.  All they’re after is the histology that is looking at them under microscope looking at the ovaries of these rats that were in the studies. It’s not hard is it and so if it’s not forthcoming you have to say they either don’t have any information are we forgot to do that or they have information? They don’t want us to know; that’s the only assumption I think that’s a fair and reasonable assumption.

So, hence, I’m stuck on the roundabout.

The final one was 23 pages of mostly redacted data, and that’s what’s on the right hand side. But they one thing they felt that was reasonable for us to note was uterine swelling and collections of clear fluid. What what was that about? I mean, that’s a concern.  That’s not normal. You know, if I didn’t ultrasound on a woman and found sort of her fluid-filled uterine cavity, it becomes me to take that investigate a little bit further. So they felt that that was appropriate for us to see.

So a college RANZCOG the College of Australia and New Zealand for obstetrician gynecologists came out with a whole pile of different points, but they really this is an 18th of August 2021. There was a bit of an unknown. What do we do with vaccines? Do we vaccinate women or not? They came out with this guideline document and the top three points were fairly clear that pregnant women are a priority group.  Pregnant women do not need to delay vaccination or avoid becoming pregnant after vaccination. And that’s a point. I have a real issue with and I’ll present the data of my own practice real world evidence has shown that it seems to be safe for pregnant women.

So they didn’t study anything. It just so happens that we’ve looked at these women and sort of comes out. Okay, so let’s go for it. And then the final thing is, and this really should I mean this implicates them, the college emphasizes the importance of inclusion of pregnant breastfeeding women in clinical trials to develop evidence-based advice. So they recognize that this and the other 12 points above these that I didn’t raise for this slide were not evidence-based. It was just consensus opinion or guideline type stuff.

So that’s pretty scary and certainly since then there are some pregnant pregnancy and breastfeeding trials that have been coming out.

My particular area of interest is hormonal deficiencies or hormonal problems in early pregnancy or infertility with regards to women not ovulating. Well, so ovulation is the process of releasing an egg that subsequently becomes fertilized and becomes a pregnancy. So that we can put all this into context, the spontaneous miscarriage rates at different age groups is what you see here in roughly in the cohort that I would work with regularly it sort of 15 to 25%. The work on the right hand side is just some recent or some previous research 2018 looking at how important hormones are for women who experience things like infertility miscarriages or ectopic pregnancies or pregnancy that doesn’t make its way down the tube into the uterine cavity. And so there’s something critical with regards to the important role that hormones play in this space and I’ll pull that out a little bit further.

This was a trial so randomized controlled trial so you get a group of women. So we had 278 women present to us with the threatened miscarriage so that they were having some spotting bleeding plus or minus pain and they were given either a placebo or progesterone the hormone progesterone to try and see whether we can decrease the likelihood of them progressing on to a miscarriage.  Now that scenario a woman who’s presenting with a threat miscarriage normally will proceed to a miscarriage about 25% of the time and so we did the numbers on the trial thought we need around about 380 to see if it’s going to make a difference and drop it to about 12-13 percent.

Interestingly what we found we pulled the trial out early makes absolutely no difference. The live birth rate was about the same 84% in both arms. So goes to show the whole pile of other things at play. It’s a very complex area, early pregnancy. And so don’t you know pretend to have any of the answers or some of the answers but it’s it’s important to show that this was a high risk pregnancy trial where we normally know 25% would proceed to miscarriage and we had 16%.  So 16%, we started throw this sort of figure around that 16% is what you would expect a miscarriage rate in a high risk population. So let’s look at this population.

Now more recently in mainstream news, we’ve found that the 85% of the population being vaccinated before covid hit the shores is not right. We know that which is no surprise, many of us were aware of that sort of data in the background, but we have to be honest with what we were being told. 85% of the population at least we were told had been vaccinated before covid hit the shores and what I’ve looked at is the college I mentioned the College of RCOG brought out a guideline on the 18th of August 2021. What I did is I looked at 11 months prior and 11 months since they brought that guideline document in I only had two women in the cohort prior to that August guideline who had been vaccinated and one sadly miscarried at 20 weeks and three days and one at seven and a bit weeks.

So the only two the only experience I had as a doctor was that the two women who had been vaccinated had both miscarried. I did not have a baby in arms. And so that alerted me to say I need to watch this space very carefully.

Now the other thing is and in terms of the data that we have it’s it’s I’d like to say it’s very tight somewhat proudly because a lot of the information that’s coming out on the pregnancy safety is population-based stuff if women remembered, and this is a particularly emotionally draining time for families a miscarriage. You’re not going to remember to go I better go to that v-safe register and note that I’ve had a miscarriage. It just doesn’t happen. We see it all the time women being asked to come for their first appointment to the hospital and then the woman says, I’m sorry. I had a miscarriage three weeks ago or five weeks ago or whatever. So that’s just the nature of the story.

And this I think is the take-home slide. Is that what I had prior to the guidelines? So the pre-vax guidelines? I had 51 pregnancies, 10 of those 51 miscarried and that was my patient cohort. Since the guideline came in in August 21, I had 62 pregnancies in the subsequent 11 months. I was busier from a pregnancy point of view because I wasn’t was no longer operating. 30 of the 62 miscarried.

Okay, so there’s something there now, I don’t pretend to say what it is. I’m just saying what I’m seeing, and that’s my practice. I’ve actually in the last few weeks decided not to practice anymore. I cannot practice in that environment. So I think and and a lot of the naysayers will say look that’s crazy. This is just because you’ve got an older cohort of women, you know during covid the only people going to be having pregnant. It’s or trying to get pregnant with those who are desperate to have a baby knowing that their time’s running out come 40 41 42. So, of course, you’re gonna have a high miscarriage rate.

Well, the reality is you’ve got 35 years of average age in the far right hand bar and 33.8 years in the left hand bar. Not much of a difference. It might be one or two percent miscarriage rate in that but certainly not double, or double and a half. And that’s still going and so I’ve got the data and I haven’t yet present or put it together, but I’ve got the 12 months because particularly with birth, you’ve got to be careful. You’ve got to capture the whole 12 months a lot of seasonal variation. So I’ve got now got September to September to September. So I’ve got 24 months - two 12 months periods irons out all the naysayers and then we should be able to actually publish.

Hopefully it’ll probably only ever stay as a preprint. So it’s implementary findings as well. So the kind of stuff we hear in the mainstream and he now published papers and I really want to bring anyone presents you a published paper, ask them "What’s the conflict?"  Almost universally there’s a significant conflict of interest that those authors have in getting that paper published.

But there are a few things in my little cohort that actually show that some of what we’re seeing in the mainstream literature is probably correct. Is of the 20 of 21 women vaccinated in pregnancy proceeded to live birth? So that’s only a sort of a 5% miscarriage rate once they’re pregnant and get vaccinating pregnancy. And that’s what we’re hearing. That’s the story they keep pushing out. They don’t talk about what about the women vaccinated just prior to pregnancy or in early pregnancy? Those who, the three of the four women who have vaccinated in early pregnancy, so that is from ovulation through to six weeks gestation. Three of the four miscarried.

Okay, and that’s the kind of stuff that is coming out in the some of the Pfizer documents that are being released. So if you capture, if it’s too early, if it’s in that preconception, and that’s what I’m finding when I drill down a little bit further if they’re being vaccinated up to the six weeks prior to conception or in the early part of pregnancy. That’s when the miscarriages happen. So it’s causing a lot of information and I’ll quickly talk about some plausible mechanisms.

There doesn’t this appear to be and I’ve only had eight women in this cohort that had a booster in this series, but they all seem to do fine. Although I note that the the one mRNA the one mRNA that TGA is accepted as being a death was a woman who had had a booster. So it’s not with that risk and the elevated miscarriage rate of late seems to be about the same in the vaccinated and under vaccinated cohort. And so that’s something that needs needs a bit more exploring.

So some plausible mechanisms and and the interesting thing is when I first sort of gave this presentation back in whenever it was it’s been a long year hasn’t it? Probably be July there really wasn’t much information out there. There’s stuff starting to come through in the mainstream literature. So I’ve just quickly put the author’s name and that but most of these papers have really just come out August/September, but we’re finding menstrual cycle changes generally by about one day.  

Up to 10% of women are having at least eight days menstrual change in the cycle of vaccination. It seems to iron itself out within one or two cycles. So it’s causing something now interestingly in that paper. They they found that women who’ve been vaccinated twice in the same cycle. Had generally a longer delayed ovulation. Okay by at least by 3.7 days. So I’ve written it as four days, but that tells me that if you captured in the second half your cycle, it’s not really going to change anything because the process is already you’ve ovulated that process is a finite amount of time. It’s not going to change but if you get in before ovulation, you’re going to jam things up a little bit and that makes sense.

So, you know, my simple take-home message would be if you’re planning or your friends or family or loved ones are planning a pregnancy try and not ideally don’t get vaccinated. But if you do get vaccinated wait at least two cycles impaired ovulation. I think at the end of the day, I look at providing hormone support for these women to support their pregnancies and overall, I found lower levels of hormones in these early pregnancies and many more have needed more hormones to support these early pregnancies, even when I’ve got a 48% miscarriage rate.

We know the liquid nanoparticle concentrates in the ovaries. We don’t know what sort of effect it has. We cannot access the histology the microscope slides of those rats. We don’t know whether it diminishes ovulation. We don’t know if it diminishes ovarian reserve.  It would be nice and at the moment I’m not aware of anyone if you’re familiar with AMH as a marker, AMH as a marker of fertility potential or reserve and no one’s really looked at what are the average? AMH rates. Yeah two or three years ago versus what they are now and it should be a very nice simple study that would bring it out very clear.

Inflammation: there is a paper that came out showing that for women who suffer from endometriosis there seems to be an exacerbation of all of their symptoms to what I’ve got is a relative risk that is a 4.3 times increase in pain a 5.5 times increase in all symptoms of endometriosis, whether they do or don’t have the disease there and endometriosis is an inflammatory condition. So this is just jumping into bed with another inflammatory condition. And so we know that that’s what’s happening.

There it seems to be there’s a couple of studies that’s one of them but that there’s a genetic predisposition to having some changes so sudden death unexplained death. There’s so we’re starting to get a little bit smarter about this and cytokines are sort of inflammatory proteins and they’re particularly you can imagine an embryo trying to land in the lining of the womb. There’s a very very tight balance between pro and anti-inflammatory cytokines. And so that’s the important thing we need to look at and and if you’re getting up regulating of all of this inflammatory system caution, no, I’m not going to even implant let alone carry that early pregnancy.

And then more recently Hannah’s paper that showed the breast milk expression of mRNA and five of 11 women. Now, there was a lot of samples I think was 130 something samples and it was only present in five. But mRNA was present in the breast milk on these women.

So from a fertility point of view, that’s a quick capture and now we’re starting to get some papers coming out and my my experience is no no, we’re near that yet. It’s not even a pre-print stage. It will be in about a month. But so it’s a scary space. And then I put that up there.

I don’t have any stickers to hand out tonight Jewel kindly let us come along to advertise tonight’s event last time so I had normal stickers out then. Okay.  So feel free to take a photo of that. Thanks. 

COVID vaccinations and fertility complications
Watch the video

 There are very real risks to fertility for those who take the COVID injections, and Dr Luke McLindon has the early data.



TRANSCRIPT:

Thanks very much, Jewel and the Voting Matters crew. It’s a great opportunity for us to be here amongst you because I guess it does give us an opportunity just to present our understanding of what the truth is in our own clinical practice. And I think that’s a critical part of the story that we’re not hearing. So thank you for your time and attention.

I guess this is me. Ordinarily I’m a surgeon. I’m a gynecological surgeon with a special interest in infertility and endometriosis surgery and that’s looked after me and my family very well and my patients for many years. The challenge with all of this is that at some point you get to the point in a career where you can’t keep making allowances for dishonesty. And that’s where I’m at. And so I’m stuck on the roundabout, but I don’t know that that’s a really big issue. Now that we’re starting to see some cracks. For me. Thanks.

Now that we’re starting to see some cracks in the the barrier of the barricade I think it’s really important that we do open our hearts to recognize that there are so many people who haven’t taken the opportunity to go a little bit further and scratch beyond the surface to find out what the truth really is in as as it relates to them. And so I think yes, there are people out there trying to silence us. The recent health regulation Health Practitioners Amendment bill that was passed is a disaster and we all recognize that we’re all on the pulse there, but unfortunately it’s only going to become more and more apparent and so for me in my own personal and professional career the point the line in the sand was back in the first of November last year; and so interestingly today is my first anniversary for having (last) operating on the patient my last patient I’ve read on was on the 25th of October last year.

So that’s a bit of a sort of it’s a pain to that. And this is where I think this one is is helpful and worthy of being aware of and humility particularly in this context is about being honest and being accepting of the truth when it presents itself and that’s I think our challenge and each one of your challenges is to try and get that message out in a kind careful cautious and loving way so that people are actually open to listening to what you’ve got to say and and that will win hearts and friends and ultimately take this whole thing down. 

Lots of writing here, but at the end of the day what we’re trying to put out was in terms of pregnancy, the impact of COVID on pregnancy is really not as bad as they made out. It took four cases of zika before it became apparent that zika has a significant impact on pregnancy. Whereas we were well into the pandemic before we sort of started to say 'Well there seems to be an increased risk of preterm birth that ptb thing up there and it seems really increased risk of stillbirth, but it’s very hard to put it all into context'. And certainly there is a case series recently of about 60 infants that sadly died of stillbirth in the setting of a mother having had COVID and found that there is a particular thing that’s very rare called placentitis, which is an inflammation of the placenta which in essence shuts down the placenta from functioning leading to stillbirth, but it’s not every baby. It’s really quite uncommon.

So normal rates of stillbirth about one in 800 term pregnancies. That is a pregnancy beyond 37 weeks in the setting. Also if you had 800 people with covid, it’s about 1.6. So it is increased but it’s only very very small and that’s the barrow they push to say well we need to vaccinate all of them. So we’ll just scratch through a little bit of that as well.

The other thing and I only had this today brought back home, which is the last line but the director general of Queensland Health of the Department of Health brought out on the 29th of September a correction or an update memo to the directive. So the directive came out in the 11th of September to say everyone Queensland Health needs to be vaccinated on the 29th. And this was a it was a point where I thought wow. There’s a little bit of sense here that we will be allowance for pregnancy exemption for anyone who was pregnant at the time of the directive 11th of September until they returned from maternity leave. So that that was reasonable. The challenge is of course the poor woman who finds out that she was pregnant on the 12th of September is not eligible for the exemption.

And in fact, I had a lady today who’s on maternity leave and she has been threatened quite seriously in writing for actually taking her maternity leave back off her because they haven’t she hasn’t provided any proof of vaccination and yet the directive was very clear the memo came out saying she’s exempt until she comes back from maternity leave. So they’re trying any foul trick to scare people and bully people into this.

I think when we talk about vaccinations, we’ve just really got to be careful of understanding, you know, and I think I’ve mentioned this before is when a new product comes to market it’ll always be its best.  A new car; It’ll be fantastic until you realize that the bearings are wrong or something not quite right and it’s exactly the same with any medical product. You’re going to have the best you can present the safest the most effective, etc. It’ll come out with a glowing school report until it starts to hit the ground running and we start to realize that there’s there’s chinks in the armor.

And so we need to recognize that there’s known and unknown harms and benefits. We just need to be honest about that. And the reality is that hasn’t been honest at all. And the minute that it starts to lose the gloss, they just go back layer upon layer of silicon just to allow the story not to stick just to keep buffing it up and make it look good.

The ace2 receptors are probably very aware of the fact that the spike protein which is the problem in this whole covid saga is that the spike protein attaches to the ACE2 receptor and that’s all the way through women’s reproductive tracks. So yes, it’s in cardiovascular systems. It’s in renal systems and affects multi systems, but particularly for women in the reproductive tract. Additionally, there’s some more recent evidence that is actually a pre-print.

So you’re probably very familiar with pre-print now probably never heard of it 12-13 months ago, but there is a pre-print showing that it also affects estrogen which one of the core hormones of women. It affects its estrogen production at a cellular level at a nuclear the nucleus of the cell. So there’s two reasons why women particularly will will be harmed you would expect by covid in the first instance, but also the purified pathology part of covid in terms of vaccine.

As a gynecologist has a particular interest in infertility my job, I guess is to go back and say well what’s that what impact of the Vac these vaccines have on my patients? Because I need to be able to be honest and tell them what the particular this is about informed consent the knowns the unknowns, what are the particular things we need to be aware of if you were to approach your GP and get vaccinated preconception, so before pregnancy, during pregnancy early pregnancy, or in breastfeeding. And it became very apparent very quickly that there just wasn’t information that I could make a call on and that’s very new. That’s quite unique.

Normally you should be able to go through scratch the surface, look around at some of these papers that are referenced in a lot of the guideline documents and and not just read the abstract the front sort of little the conclusion but actually read the nuts and bolts because often the conclusion that’s presented in the abstract.  It comes out of thin air.

It’s like hell on Earth did they get that conclusion out of what they’ve just written, and that happens more and more and more frequently of late.  But these are just some freedom of information application numbers that relate to reproduction and in essence some of the things that we worry about are the lipid nanoparticle, which is the little wrapping around the MRNA component of the vaccine seems to have a preponderance for the ovaries. So 10 times higher concentration in the ovaries the most other areas of the body aside from the liver in this plane, but the ovaries don’t have the ability to regenerate or reconstitute themselves unlike liver.

So that that’s a problem the controls when they looked at the mice models with our rats rather than mice with our rat models and they found that in the control group the miscarriage rate was a whole lot less in fact half. So 4.1% versus 9.8% compared to the actual intervention arm. That is the actual Pfizer that Pfizer had three doses in this study, but the found that it was 9.8% it automatically that should sort of at least raise some concerns. It doesn’t they just passed it aside and said that’s okay it fits in historical miscarriage rates for these sort of studies.

The Freedom of Information 2565 is still undergoing an application. So it just it’s been put in rejected come back adjusted put in again rejected come back. It’s gone to the information commissioner. It’s gone the out Ombudsman. It’s a formal complaint as of interestingly. It’s first anniversary as well 25th of October and it’s still an unresolved issue. You’d think they are after the crown jewels. They’re not.  All they’re after is the histology that is looking at them under microscope looking at the ovaries of these rats that were in the studies. It’s not hard is it and so if it’s not forthcoming you have to say they either don’t have any information are we forgot to do that or they have information? They don’t want us to know; that’s the only assumption I think that’s a fair and reasonable assumption.

So, hence, I’m stuck on the roundabout.

The final one was 23 pages of mostly redacted data, and that’s what’s on the right hand side. But they one thing they felt that was reasonable for us to note was uterine swelling and collections of clear fluid. What what was that about? I mean, that’s a concern.  That’s not normal. You know, if I didn’t ultrasound on a woman and found sort of her fluid-filled uterine cavity, it becomes me to take that investigate a little bit further. So they felt that that was appropriate for us to see.

So a college RANZCOG the College of Australia and New Zealand for obstetrician gynecologists came out with a whole pile of different points, but they really this is an 18th of August 2021. There was a bit of an unknown. What do we do with vaccines? Do we vaccinate women or not? They came out with this guideline document and the top three points were fairly clear that pregnant women are a priority group.  Pregnant women do not need to delay vaccination or avoid becoming pregnant after vaccination. And that’s a point. I have a real issue with and I’ll present the data of my own practice real world evidence has shown that it seems to be safe for pregnant women.

So they didn’t study anything. It just so happens that we’ve looked at these women and sort of comes out. Okay, so let’s go for it. And then the final thing is, and this really should I mean this implicates them, the college emphasizes the importance of inclusion of pregnant breastfeeding women in clinical trials to develop evidence-based advice. So they recognize that this and the other 12 points above these that I didn’t raise for this slide were not evidence-based. It was just consensus opinion or guideline type stuff.

So that’s pretty scary and certainly since then there are some pregnant pregnancy and breastfeeding trials that have been coming out.

My particular area of interest is hormonal deficiencies or hormonal problems in early pregnancy or infertility with regards to women not ovulating. Well, so ovulation is the process of releasing an egg that subsequently becomes fertilized and becomes a pregnancy. So that we can put all this into context, the spontaneous miscarriage rates at different age groups is what you see here in roughly in the cohort that I would work with regularly it sort of 15 to 25%. The work on the right hand side is just some recent or some previous research 2018 looking at how important hormones are for women who experience things like infertility miscarriages or ectopic pregnancies or pregnancy that doesn’t make its way down the tube into the uterine cavity. And so there’s something critical with regards to the important role that hormones play in this space and I’ll pull that out a little bit further.

This was a trial so randomized controlled trial so you get a group of women. So we had 278 women present to us with the threatened miscarriage so that they were having some spotting bleeding plus or minus pain and they were given either a placebo or progesterone the hormone progesterone to try and see whether we can decrease the likelihood of them progressing on to a miscarriage.  Now that scenario a woman who’s presenting with a threat miscarriage normally will proceed to a miscarriage about 25% of the time and so we did the numbers on the trial thought we need around about 380 to see if it’s going to make a difference and drop it to about 12-13 percent.

Interestingly what we found we pulled the trial out early makes absolutely no difference. The live birth rate was about the same 84% in both arms. So goes to show the whole pile of other things at play. It’s a very complex area, early pregnancy. And so don’t you know pretend to have any of the answers or some of the answers but it’s it’s important to show that this was a high risk pregnancy trial where we normally know 25% would proceed to miscarriage and we had 16%.  So 16%, we started throw this sort of figure around that 16% is what you would expect a miscarriage rate in a high risk population. So let’s look at this population.

Now more recently in mainstream news, we’ve found that the 85% of the population being vaccinated before covid hit the shores is not right. We know that which is no surprise, many of us were aware of that sort of data in the background, but we have to be honest with what we were being told. 85% of the population at least we were told had been vaccinated before covid hit the shores and what I’ve looked at is the college I mentioned the College of RCOG brought out a guideline on the 18th of August 2021. What I did is I looked at 11 months prior and 11 months since they brought that guideline document in I only had two women in the cohort prior to that August guideline who had been vaccinated and one sadly miscarried at 20 weeks and three days and one at seven and a bit weeks.

So the only two the only experience I had as a doctor was that the two women who had been vaccinated had both miscarried. I did not have a baby in arms. And so that alerted me to say I need to watch this space very carefully.

Now the other thing is and in terms of the data that we have it’s it’s I’d like to say it’s very tight somewhat proudly because a lot of the information that’s coming out on the pregnancy safety is population-based stuff if women remembered, and this is a particularly emotionally draining time for families a miscarriage. You’re not going to remember to go I better go to that v-safe register and note that I’ve had a miscarriage. It just doesn’t happen. We see it all the time women being asked to come for their first appointment to the hospital and then the woman says, I’m sorry. I had a miscarriage three weeks ago or five weeks ago or whatever. So that’s just the nature of the story.

And this I think is the take-home slide. Is that what I had prior to the guidelines? So the pre-vax guidelines? I had 51 pregnancies, 10 of those 51 miscarried and that was my patient cohort. Since the guideline came in in August 21, I had 62 pregnancies in the subsequent 11 months. I was busier from a pregnancy point of view because I wasn’t was no longer operating. 30 of the 62 miscarried.

Okay, so there’s something there now, I don’t pretend to say what it is. I’m just saying what I’m seeing, and that’s my practice. I’ve actually in the last few weeks decided not to practice anymore. I cannot practice in that environment. So I think and and a lot of the naysayers will say look that’s crazy. This is just because you’ve got an older cohort of women, you know during covid the only people going to be having pregnant. It’s or trying to get pregnant with those who are desperate to have a baby knowing that their time’s running out come 40 41 42. So, of course, you’re gonna have a high miscarriage rate.

Well, the reality is you’ve got 35 years of average age in the far right hand bar and 33.8 years in the left hand bar. Not much of a difference. It might be one or two percent miscarriage rate in that but certainly not double, or double and a half. And that’s still going and so I’ve got the data and I haven’t yet present or put it together, but I’ve got the 12 months because particularly with birth, you’ve got to be careful. You’ve got to capture the whole 12 months a lot of seasonal variation. So I’ve got now got September to September to September. So I’ve got 24 months - two 12 months periods irons out all the naysayers and then we should be able to actually publish.

Hopefully it’ll probably only ever stay as a preprint. So it’s implementary findings as well. So the kind of stuff we hear in the mainstream and he now published papers and I really want to bring anyone presents you a published paper, ask them "What’s the conflict?"  Almost universally there’s a significant conflict of interest that those authors have in getting that paper published.

But there are a few things in my little cohort that actually show that some of what we’re seeing in the mainstream literature is probably correct. Is of the 20 of 21 women vaccinated in pregnancy proceeded to live birth? So that’s only a sort of a 5% miscarriage rate once they’re pregnant and get vaccinating pregnancy. And that’s what we’re hearing. That’s the story they keep pushing out. They don’t talk about what about the women vaccinated just prior to pregnancy or in early pregnancy? Those who, the three of the four women who have vaccinated in early pregnancy, so that is from ovulation through to six weeks gestation. Three of the four miscarried.

Okay, and that’s the kind of stuff that is coming out in the some of the Pfizer documents that are being released. So if you capture, if it’s too early, if it’s in that preconception, and that’s what I’m finding when I drill down a little bit further if they’re being vaccinated up to the six weeks prior to conception or in the early part of pregnancy. That’s when the miscarriages happen. So it’s causing a lot of information and I’ll quickly talk about some plausible mechanisms.

There doesn’t this appear to be and I’ve only had eight women in this cohort that had a booster in this series, but they all seem to do fine. Although I note that the the one mRNA the one mRNA that TGA is accepted as being a death was a woman who had had a booster. So it’s not with that risk and the elevated miscarriage rate of late seems to be about the same in the vaccinated and under vaccinated cohort. And so that’s something that needs needs a bit more exploring.

So some plausible mechanisms and and the interesting thing is when I first sort of gave this presentation back in whenever it was it’s been a long year hasn’t it? Probably be July there really wasn’t much information out there. There’s stuff starting to come through in the mainstream literature. So I’ve just quickly put the author’s name and that but most of these papers have really just come out August/September, but we’re finding menstrual cycle changes generally by about one day.  

Up to 10% of women are having at least eight days menstrual change in the cycle of vaccination. It seems to iron itself out within one or two cycles. So it’s causing something now interestingly in that paper. They they found that women who’ve been vaccinated twice in the same cycle. Had generally a longer delayed ovulation. Okay by at least by 3.7 days. So I’ve written it as four days, but that tells me that if you captured in the second half your cycle, it’s not really going to change anything because the process is already you’ve ovulated that process is a finite amount of time. It’s not going to change but if you get in before ovulation, you’re going to jam things up a little bit and that makes sense.

So, you know, my simple take-home message would be if you’re planning or your friends or family or loved ones are planning a pregnancy try and not ideally don’t get vaccinated. But if you do get vaccinated wait at least two cycles impaired ovulation. I think at the end of the day, I look at providing hormone support for these women to support their pregnancies and overall, I found lower levels of hormones in these early pregnancies and many more have needed more hormones to support these early pregnancies, even when I’ve got a 48% miscarriage rate.

We know the liquid nanoparticle concentrates in the ovaries. We don’t know what sort of effect it has. We cannot access the histology the microscope slides of those rats. We don’t know whether it diminishes ovulation. We don’t know if it diminishes ovarian reserve.  It would be nice and at the moment I’m not aware of anyone if you’re familiar with AMH as a marker, AMH as a marker of fertility potential or reserve and no one’s really looked at what are the average? AMH rates. Yeah two or three years ago versus what they are now and it should be a very nice simple study that would bring it out very clear.

Inflammation: there is a paper that came out showing that for women who suffer from endometriosis there seems to be an exacerbation of all of their symptoms to what I’ve got is a relative risk that is a 4.3 times increase in pain a 5.5 times increase in all symptoms of endometriosis, whether they do or don’t have the disease there and endometriosis is an inflammatory condition. So this is just jumping into bed with another inflammatory condition. And so we know that that’s what’s happening.

There it seems to be there’s a couple of studies that’s one of them but that there’s a genetic predisposition to having some changes so sudden death unexplained death. There’s so we’re starting to get a little bit smarter about this and cytokines are sort of inflammatory proteins and they’re particularly you can imagine an embryo trying to land in the lining of the womb. There’s a very very tight balance between pro and anti-inflammatory cytokines. And so that’s the important thing we need to look at and and if you’re getting up regulating of all of this inflammatory system caution, no, I’m not going to even implant let alone carry that early pregnancy.

And then more recently Hannah’s paper that showed the breast milk expression of mRNA and five of 11 women. Now, there was a lot of samples I think was 130 something samples and it was only present in five. But mRNA was present in the breast milk on these women.

So from a fertility point of view, that’s a quick capture and now we’re starting to get some papers coming out and my my experience is no no, we’re near that yet. It’s not even a pre-print stage. It will be in about a month. But so it’s a scary space. And then I put that up there.

I don’t have any stickers to hand out tonight Jewel kindly let us come along to advertise tonight’s event last time so I had normal stickers out then. Okay.  So feel free to take a photo of that. Thanks.